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Effective imaging up to 900 μm in the mouse brain, crucial for studying deep cortical layers.
Utilizes a deformable mirror to correct for system-level nonlinearities and optical aberrations, enabling sharp imaging across the entire 50 mm² area.
Optimized for in vivo studies, involving anaesthetized animals to maintain consistency.
The system, likely utilizing a variant described as VAM_GS (possibly a reference to Volumetric Adaptive Microscopy/Gaussian Stacking or similar technique), focuses on maintaining high resolution across a large, non-flat area.
The ULTRA system is specifically designed for complex, multi-regional brain studies.
It allows researchers to visualize brain structures spanning from superficial layers down to 900 μm depth in a single study.
The system sequences through Zernike modes to compensate for aberrations, with optimization processes sometimes completing in minutes, tailored for high-speed scanning (e.g., 133 Hz for ROI).
It achieves cellular resolution across an ultra-large FOV exceeding 50 mm².
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