Due to the gap in production, many original actors' contracts had lapsed, leading to a substantial "revamp" of the supporting cast.

: Poppy Montgomery (Carrie Wells), Dylan Walsh (Al Burns), and James Hiroyuki Liao (Jay Lee) were the only core regulars to return. New Regulars :

as Captain Sandra Russo, the team’s new boss. Alani "La La" Anthony as medical examiner Delina Michaels. E.J. Bonilla as Detective Denny Padilla.