Sensing: The C2D domain is identified as critical, as disruptions in this area alter synaptic sound encoding.

It tethers vesicles to the plasma membrane, facilitating sound encoding.

The protein utilizes several C2 domains (C2A-C2F) to bind Ca 2+raised to the 2 plus power and lipids, as shown in the protein structure below. 2. C2 Domains: Function & Interactions

ions are bound per domain, with specific significance for the .

The study highlights that membrane binding involves a cooperative effort of multiple domains.

The binding requires cooperation between multiple C2 domains to secure the vesicle to the target membrane.

Structure and function of otoferlin, a synaptic protein of ... - PMC