: Miles Morales' uncle, who serves as a fearsome, high-tech enforcer for Kingpin. He uses sharp metal claws that can extend into lasers.
: Featured in the comic book Spider-Verse events and referenced in wider lore, these are interdimensional vampires who feed on the life force of "Spider-Totems" across all realities. Enemy Combat Guide (Video Games)
In games featuring Spider-Verse characters, enemies often require specific tactics to overcome.
: The central threat in Into the Spider-Verse . He built the Super-Collider to bring back his family, an act that threatened to collapse the entire multiverse. His signature combat move is a "Ground Punch," a powerful hammer blow that generates shockwaves.
: A monstrous, behemoth-sized version of the classic villain. In this universe, he is a pyrokinetic who can summon devastating fireballs.
: The primary antagonist of Across the Spider-Verse . He can create and manipulate interdimensional portals, allowing him to travel through the multiverse. He is capable of redirecting attacks by absorbing them through the portals on his body.