The arms' artificial intelligence begins to influence Otto’s mind, driving him to complete his dangerous experiment at any cost, even if it threatens to destroy New York City. The Hero’s Return
His grades at university are slipping because he can't focus on his studies. Spider-Man 2 (2004)
His best friend, Harry Osborn, hates Spider-Man for the death of his father, and Mary Jane Watson—the love of Peter's life—is engaged to John Jameson. Spider-Man 2 (2004)
While Peter tries to live a normal life, a new threat emerges. Brilliant scientist —whom Peter had befriended and admired—is involved in a lab accident during a fusion experiment. Spider-Man 2 (2004)