The two sides have faced off frequently in both the UEFA Champions League and the Europa League over the last few seasons:
: PSV held the edge in the group stage, drawing 2–2 at home before winning 3–2 in Spain. Sevilla - PSV
: Sevilla’s Lucas Ocampos was sent off in the 66th minute after receiving two yellow cards in quick succession. The two sides have faced off frequently in
: Sevilla appeared to be in control after goals from Sergio Ramos and Youssef En-Nesyri gave them a 2–0 lead by the 47th minute. Sevilla - PSV