: Because amantadine binds to proteins, it cannot be cleared via dialysis. House must inform a devastated Wilson that there is no cure. Major Themes
: House’s subconscious manifests a guide who prompts him to identify the patient. He eventually realizes her necklace is made of amber, signifying that the "dying patient" is actually Amber Volakis , Wilson’s girlfriend. [S4E16] House's Head (Part 2)
: The episode concludes with Thirteen testing positive for Huntington’s disease, echoing the theme that life is often "unfair" and beyond a doctor's control. : Because amantadine binds to proteins, it cannot
: House deduces that Amber was taking amantadine for the flu. The crash caused acute kidney failure, preventing her body from processing the drug and resulting in lethal amantadine poisoning. He eventually realizes her necklace is made of
: The finale fundamentally alters the series' core relationship. Wilson is left alone, finding a final note from Amber, while House awakens from a coma to face the wreckage of his friendship.
: The recovered memory reveals that House, too drunk to drive, called Wilson for a ride; Amber arrived instead. They were on the bus together when the accident occurred. The Medical and Moral Failure