, such as droplets fusing together or recovering after being bleached by a laser (FRAP).
: Under normal conditions, G3BP is in a compact, "auto-inhibited" state. g8046.mp4
: The protein G3BP (GTPase-activating protein-binding protein) acts as a central "node" or switch for granule formation. , such as droplets fusing together or recovering
The video visualizes the cellular processes of . Stress granules are "membraneless organelles" that form when a cell is under stress, such as oxidative stress or heat. Key scientific takeaways associated with this file include: The video visualizes the cellular processes of
of stress granules forming in living HeLa cells.
This research is significant because it explains how cells quickly organize their internal machinery to survive harsh conditions, a process linked to neurodegenerative diseases when it goes awry.
is a supplemental video file from a high-profile scientific study titled "RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation," published in the journal Cell in April 2020. Scientific Context