(2026): Published in Critical Care , this paper provides a comprehensive overview of dead space from its first description by Christian Bohr in 1891 to modern applications. It discusses the integration of lung imaging and clinical scenarios to assess dead space distribution in critical care settings.
: This study, available on PMC , highlights that measuring dead space can be a more reliable predictor of Acute Respiratory Distress Syndrome (ARDS) outcomes than oxygenation levels alone. It evaluates various surrogate indices, such as the ventilatory ratio, used in clinical practice when direct measurement is unavailable.
: Found in the European Respiratory Journal , this paper explains that elevated physiological dead space is a strong prognostic marker for patients with ARDS and severe heart failure. It identifies ventilation/perfusion ( ) heterogeneity as a primary pathophysiological mechanism.
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