"Structural snapshots of La Crosse virus polymerase reveal the mechanisms of transcription initiation and elongation" analyzes the 260 kDa L protein of the La Crosse virus (LACV) using cryo-electron microscopy. The study captures the enzyme's structural shifts during transcription and replication, offering insights into its de novo initiation mechanism and potential for antiviral drug development. Read the full document at HAL open science .