24227.rar Apr 2026

Input overload: Contributions of retinoic acid signaling feedback to retinoid homeostasis Authors: Andrea Janesick, Bruce Blumberg, and others.

You can find the full text and original figures on the Wiley Online Library . 24227.rar

The paper investigates how excess RA triggers its own degradation (via Cyp26 enzymes) and how depletion leads to compensatory receptor expression. A version of the manuscript is also available

A version of the manuscript is also available through PMC (National Library of Medicine) . The paper explores how retinoic acid (RA) signaling

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The paper explores how retinoic acid (RA) signaling uses feedback loops to maintain stable levels of Vitamin A metabolites, specifically examining the role of Retinoic Acid Receptors (RARs) and enzymes like Cyp26. Content Summary

It discusses the role of Retinoic Acid Response Elements (RAREs) in promoters as sensors that modulate the expression of retinoid-related genes.