109595 Site

: It also refers to a recent eLife reviewed preprint (109595) that uses fruit flies to model RVCL-S , a rare genetic disease affecting blood vessels in the brain and retina.

: While this "primed" state might seem helpful for fighting infections, it often leads to pathological inflammation , increasing the risk for cardiovascular diseases, autoimmune disorders, and severe inflammatory responses (such as those seen in COVID-19). Critical Review and Assessment 109595

: Experts note that while the "priming" is clearly observed, the exact duration of these epigenetic changes remains an open question for future research. : It also refers to a recent eLife

: In both mice and humans, chronic stress was found to reprogram myeloid progenitor cells in the bone marrow. This leads to an increased production of monocytes that are more reactive to future threats. : In both mice and humans, chronic stress

: The study is lauded for its translational approach , showing consistent results across both animal models and human subjects, which adds high clinical relevance.

: The study identifies specific epigenetic changes—molecular "marks" on DNA—that alter how immune cells respond to inflammation even after the stressor is removed.